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Cyclic pifithrin-a

WebJul 17, 2024 · Cell-based assays in multiwell plates are widely used for radiosensitivity and chemosensitivity assessment with different mammalian cell types. Despite their relative ease of performance, such assays lack specificity as they do not distinguish between the cytostatic (reversible/sustained growth arrest) and cytotoxic (loss of viability) effects of … WebPifithrin-α, p-nitro, cyclic Pifithrin-α, p-nitro, cyclic is A cell-permeable p53 inhibitor that is more potent & has a longer half-life than Pifithrin-α. 60477-38-5 sc-222177 sc-222177A sc-222177B sc-222177C : 5 mg 10 mg 25 mg 50 mg: $164.00 $300.00 $600.00 1

Cyclic Pifithrin-α hydrobromide (3843) Bio-Techne

WebMay 10, 2016 · In this study, we optimized reprogramming approaches for hUCs with very poor proliferation. We report here that a compound cocktail containing cyclic pifithrin-a (a P53 inhibitor), A-83-01, CHIR99021, thiazovivin, NaB, and PD0325901 significantly improves the reprogramming efficiency (170-fold more) for hUCs. In addition, we showed … WebPifithrin-α A cell-permeable chemical inhibitor of p53. Synonym (s): Pifithrin-α, 2- (2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1- p-tolylethanone, HBr Empirical Formula (Hill Notation): C16H18N2OS · xHBr CAS Number: 63208-82-2 Molecular Weight: 286.39 (free base basis) MDL number: MFCD00417851 fifdedu https://thephonesclub.com

Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to

WebCyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke−induced apoptosis of pulmonary endothelial cells. [ 1] Packaging 5, 10 mg in … WebPifithrin-β (Synonyms: PFT β; Cyclic Pifithrin-α) Cat. No.: HY-16702 Data Sheet Handling Instructions Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM. For research use only. We do not sell to patients. Pifithrin-β Chemical Structure CAS No. : 60477-34-1 * Please select Quantity before adding items. WebCyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α a small molecule inhibitor of p53. It reversibly inhibits p53-dependent transactivation of p53-responsive genes and … griff shepherds bush

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Category:Cyclic pifithrin-alpha-p-nitro, transcriptional p53 inhibitor (CAS ...

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Cyclic pifithrin-a

Cyclic Pifithrin-α Sensitizes Wild Type p53 Tumor Cells to ...

WebJan 23, 2024 · Pifithrin-α (PFT-α) is a small molecule which has been widely used as a specific inhibitor of p53 transcription activity. However, its molecular mechanism of action … WebCyclic Pifithrin-α hydrobromide Tocris Bioscience a Bio-Techne Brand Catalog # 3843 Citations (1) COA / SDS Catalog # Availability Size / Price Qty 797-B2-025 In Stock 25 ug / $394.00 Add To Cart Print Quote Bulk Order Key Product Details Order Information Bio-Techne Corporation tel: (800) 343-7475 (free phone) tel: (612) 379-2956

Cyclic pifithrin-a

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WebKey features and details. Cell-permeable transcriptional p53 inhibitor. CAS Number: 60477-38-5. Purity: > 99%. Soluble in DMSO to 10 mM. Form / State: Solid. WebJul 1, 2008 · (PDF) Cyclic Pifithrin-α Sensitizes Wild Type p53 Tumor Cells to Antimicrotubule Agent–Induced Apoptosis 1 Cyclic Pifithrin-α Sensitizes Wild Type p53 Tumor Cells to Antimicrotubule...

WebPifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in … http://shiji.cnreagent.com/s/sv253508.html

WebCyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α a small molecule inhibitor of p53. It reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis, with less cytotoxicity than the parent compound. Potent STAT6 transcriptional inhibitor.

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WebPifithrin-α (PFT-α; Item No. 13326) is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. 1 Cyclic PFT-α (Item No. 14748) is a stable analog of PFT-α. 2 p -nitro-Cyclic PFT-α is a cell-permeable form of cyclic PFT-α. 3 It is one order of magnitude more active that PFT-α in protecting cortical neurons exposed … fifco historiaWebCyclic pifithrin-alpha-p-nitro, transcriptional p53 inhibitor(PFT-α) 是一种 p53 的灭活剂，可阻断 p53 依赖性转录激活和细胞凋亡。 Cyclic PFT-α 是 PFT-α 的稳定类似物。 p-nitro-Cyclic PFT-α 是一种可渗透细胞的环状 PFT-α。 在保护暴露于依托泊苷 (ED50 = 30 nM) 的皮质神经元方面，它比 ... griffs ice house belknapWebCyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke−induced apoptosis of pulmonary endothelial cells. Packaging 5, 10 mg in glass bottle Protect from light. Biochem/physiol Actions A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity. griffs ice house grand rapidsWebPifithrin-α is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. Pifithrin-α enhances … griffs ice house holland miWebCyclic Pifithrin- α hydrobromide is a cyclic analog of pifithrin- α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone -induced cell death in murine … fifco onlineWebCyclic Pifithrin-alpha Hydrobromide 98.0 %, TCI America Fisher Scientific Fisher Scientific Fisher Healthcare Fisher Science Education Sign Up for Email Help & Support … griffs ice house georgetownWebMar 15, 2005 · All of the new analogues, Pifithrin-like and polycyclic dehydrated derivatives were assessed for their p53 inactivation potency by measuring survival of cortical neurons, whose death was induced by the DNA-damaging agent etoposide. Pifithrin-alpha like 2f as well as the cyclic dehydrated 6b analogue were found to be one log more potent p53 ... griffs ice arena georgetown