Chromokinesins
WebNov 10, 2014 · These experiments demonstrate that chromokinesin-mediated PEFs are active on polar chromosomes, but kinetochore forces are dominant to move peripheral chromosomes poleward (by dynein) and,... WebApr 11, 2024 · A. Left: Schematics of the rationale of our kinesin-based chromosome mis-segregation approach. Chromosome congression toward the spindle equator is facilitated by KT-MT attachments and plus-end-directed microtubule-based motors, such as chromokinesins at chromosome arms, and CENP-E at kinetochores (KTs).
Chromokinesins
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WebJan 1, 2015 · Chromokinesins KIF4A and KID are unique amongst kinesins in their localization during mitosis (Fig. 9.1).Both proteins associate along the axis of condensed chromosome arms during mitosis [].This prominent localization points to a possible role of these motor proteins in chromosome architecture and chromosome movement during … WebJan 1, 2015 · Chromokinesins KIF4A and KID are unique amongst kinesins in their localization during mitosis (Fig. 9.1).Both proteins associate along the axis of condensed …
WebAug 23, 2004 · Both types of chromokinesins are nuclear during interphase and localize on condensed chromosome arms during mitosis. In humans, two KIF4 members exist: HKIF4A and HKIF4B (Ha et al., 2000). Human KIF4A (HKIF4A) is a 140-kD protein that contains several conserved structural motifs including a kinesin-like motor domain, a long coiled … WebChromokinesins are microtubule plus end–directed motor proteins that bind to chromosome arms. In Xenopus egg cell-free extracts, Xkid and Xklp1 are essential for …
WebMay 15, 2012 · We demonstrate that polar ejection forces are antagonistically modulated by chromokinesins. These pushing forces depend on Kid (kinesin-10) activity and are antagonized by Kif4A (kinesin-4), which functions to directly suppress microtubule growth. WebMolecular motors generate cellular forces and act in a multitude of intracellular transport processes. The chromokinesins are a subgroup of kinesin motors. Chromokinesins act in various steps of mitosis, including chromosome condensation, metaphase alignment, chromosome segregation, cytokinesis and they help maintain genome stability. The …
WebMedChemExpress References: PMID: 36989031 DNA damage response (DDR) during interphase involves active signaling and repair to ensure genomic stability. However, how mitotic cells respond to DNA damage remains poorly understood. Supported by correlative live-/fixed-cell microscopy, it was found that mitotic cells exposed to several Cancer …
WebRegarding the function of kinetochore motors that influence chromosome congression movement, perturbation of CENP-E and chromokinesins can influence the maintenance of alignment of chromosomes at the equator [19,51,52,53], but it is not clear if this is related to the same mechanical causes as during congression. 4. Biomechanical and Molecular ... siding contractors orange county casiding contractors rahway njWebJul 1, 2005 · Chromokinesins are clearly crucial components of the mitotic machinery and are required for accurate genome segregation. Not surprisingly, loss of chromokinesin … the political history of modern japanWebOct 8, 2024 · Chromokinesins are members of the kinesin superfamily that harbour a specific DNA-binding domain. The best characterized chromokinesins belong to the … the politicalization of willie hortonWebOct 8, 2024 · Chromokinesins are members of the kinesin superfamily that harbour a specific DNA-binding domain. The best characterized chromokinesins belong to the kinesin-4/Kif4 and kinesin-10/Kif22 … the political genius of abraham lincolnWebSep 21, 2011 · The bipolar spindle is a highly dynamic structure that assembles transiently around the chromosomes and provides the mechanical support and the forces required for chromosome segregation. Spindle assembly and chromosome movements rely on the regulation of microtubule dynamics and a fine balance of forces exerted by various … the political hopeful recognizedWebMay 12, 2024 · Chromokinesins are motor proteins that interact with both microtubules and chromatin (Mazumdar and Misteli, 2005; Vanneste et al., 2011). Two well-characterized chromokinesin genes in Drosophila are the kinesin-10–related motor Nod (Theurkauf and Hawley, 1992) and the kinesin-4–related motor Klp3a (Williams et al., 1995). To … the political economy of trade policy