WebThe BET (bromodomain and extra-terminal domain) family proteins, consisting of BRD2, BRD3, BRD4, and testis-specific BRDT, are widely acknowledged as major transcriptional regulators in biology. They are characterized by two tandem bromodomains (BDs) that bind to lysine-acetylated histones and transcription factors, recruit transcription factors and … WebMar 19, 2024 · Bromodomain inhibitors revisited. Bromodomain and extraterminal domain (BET) proteins contribute to the pathogenesis of cancer and immune diseases through their effects on transcriptional regulation. BET proteins contain two nearly identical bromodomains, BD1 and BD2, structural modules that have attracted great interest as …
Current Understanding of the Role of the Brd4 Protein in the ...
WebResults suggest structure-based drug design of bromodomain-containing protein 4 (Brd4) inhibitors. PMID: 27494802; Cells harboring the fusion gene are selectively sensitive to small-molecule inhibition of protein targets induced by, or bound to, PAX3-FOXO1-occupied super enhancers. WebNovel strategies targeting bromodomain-containing protein 4 (BRD4) for cancer drug discovery. / Liang, Dailin; Yu, Yifan; Ma, Zonghui. In: European journal of medicinal chemistry, Vol. 200, 112426, 15.08.2024. Research output: Contribution to journal › Review article › peer-review clas ohlson headset bluetooth
Cells Free Full-Text Bromodomain Protein Inhibitors …
WebBromodomain-containing protein 4 (BRD4), a member of the bromodomain and extraterminal (BET) protein family, plays an important role in controlling oncogene expression and genome stability. In recent years, numerous BRD4 inhibitors have entered clinical trials and achieved exciting results in tumor treatment. Recent clinical studies … WebBromodomain protein 4 (BRD4) is a chromatin-binding protein implicated in cancer and autoimmune diseases that functions as a scaffold for transcription factors at promoters and super-enhancers. Although chromatin decompaction and transcriptional activation of target genes are associated with BRD4 binding, the mechanisms involved are unknown. WebNov 9, 2024 · Bromodomain-containing protein 4 (BRD4) is an epigenetic reader and oncology drug target that regulates gene transcription through binding to acetylated chromatin via bromodomains. Phosphorylation ... download free relax music